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KMID : 0043319960190020148
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Archives of Pharmacal Research
1996 Volume.19 No. 2 p.148 ~ p.152
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Synthesis of 4-(2-thiazolyloxy)phenylalkanoic Acids As An An-tiinflammatory Agent
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Choi Hong-Dae
Shin Sang-Hoon
Son Byeng-Wha
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Abstract
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The efficient synthesis of 4-(2-thiazolyloxy)phenylalkanoic acids (10a-c), which are a potent antiinflammatory agent, was achieved in 5-6 steps starting from isopropoxybenzene and methyl . The key intermediate (4) was prepared by Friedel-Crafts reaction of isopropoxybenzene with (1) followed by desulfurization and the removal of isopropyl protector. Methyl 4-hydroxyphenylalkanoates (6, 8) were similarly obtained from alkylation of (3) and deprotection.
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KEYWORD
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4-(2-Thiazolyoxy)phenylalkanoic acids, Antiinflammatory agent, Methyl, Friedel-Crafts reaction, Desulfurization, Isopropyl protector, Methyl 4-hy-droxyphenylalkanoates, Alkylation, Deprotection
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